Helping Thy Neighbors Spillover at the Mossy Fiber Glomerulus
نویسنده
چکیده
Neurotransmitter "spillover" between neighboring synapses challenges the principle of synapse specificity. In this issue of Neuron, show that release from neighboring presynaptic sites contributes significantly to AMPA receptor-mediated postsynaptic currents at cerebellar mossy fiber synapses. Unexpectedly, spillover is predicted to improve the reliability and reduce the variability of transmission at this glomerular synapse.
منابع مشابه
GABA spillover from single inhibitory axons suppresses low-frequency excitatory transmission at the cerebellar glomerulus.
GABA type B receptors (GABA(B)-Rs) are present on excitatory terminals throughout the CNS, but surprisingly little is known about their role in modulating neurotransmission under physiological conditions. We have investigated activation of GABA(B)-Rs on excitatory terminals within the cerebellar glomerulus, a structure where glutamatergic excitatory and GABAergic inhibitory terminals are in clo...
متن کاملSpillover-Mediated Transmission at Inhibitory Synapses Promoted by High Affinity α6 Subunit GABAA Receptors and Glomerular Geometry
synapses. Spillover of transmitter introduces a divergence of information flow superimposed on that produced by divergence in the wiring of synaptic connections. In the case of glutamate, it may also have significant implications for our understanding of the mechanisms Although a modulation of excitatory transmission by Summary GABA spillover has been observed in the hippocampus (Isaacson et al...
متن کاملUltrastructural contributions to desensitization at cerebellar mossy fiber to granule cell synapses.
Postsynaptic AMPA receptor desensitization leads to depression at some synapses. Here we examine whether desensitization occurs at mossy fiber to granule cell synapses and how synaptic architecture could contribute. We made whole-cell voltage-clamp recordings from granule cells in rat cerebellar slices at 34 degrees C, and stimulated mossy fibers with paired pulses. The amplitude of the second ...
متن کاملModeling of slow glutamate diffusion and AMPA receptor activation in the cerebellar glomerulus.
Synaptic conductances are influenced markedly by the geometry of the space surrounding the synapse since the transient glutamate concentration in the synaptic cleft is determined by this geometry. Our paper is an attempt to understand the reasons for slow glutamate diffusion in the cerebellar glomerulus, a structure situated around the enlarged mossy fiber terminal in the cerebellum and surroun...
متن کاملSpillover-mediated transmission at inhibitory synapses promoted by high affinity alpha6 subunit GABA(A) receptors and glomerular geometry.
Divergence and convergence of synaptic connections make a crucial contribution to the information processing capacity of the brain. Until recently, it was thought that transmitter released at a synapse affected only a specific postsynaptic cell. We show here that spillover of inhibitory transmitter at the Golgi to granule cell synapse produces significant cross-talk to non-postsynaptic cells, w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuron
دوره 35 شماره
صفحات -
تاریخ انتشار 2002